Idiopathic Hypereosinophilic Syndrome Presenting as Severe Loeffler's Endocarditis

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Idiopathic hypereosinophilic syndrome presenting as severe Loeffler's endocarditis.

Loeffler ’s endocarditis, also known as Loeffler ’s endomyocardial disease, was first described by Wilhelm Loeffler in a patient with progressive heart failure due to eosinophilic infiltration of the endomyocardium, which was found to be secondary to peripheral eosinophilia1. It appears to be a subset of hypereosinophilic syndrome (HES), in which the heart is predominantly involved, characteriz...

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Idiopathic hypereosinophilic syndrome presenting as childhood hemiplegia.

A case of childhood hemiplegia due to idiopathic hypereosinophilic syndrome is reported. There was no cardiac lesion. The neurological complications associated with hypereosinophilic syndrome and the pathophysiological mechanism of neurotoxicity of human eosinophils are discussed. It is likely that the neurological deficit was due to eosinophilic neurotoxicity.

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Idiopathic Hypereosinophilic Syndrome

Idiopathic hypereosinophilic syndrome is a multisystem disease with peripheral blood eosinophilia of at least 6 months duration, multiple organ system involvement, and no evidence for other known causes of eosinophilia. It is characteristically a disease of middle-aged men, often has a poor prognosis and is seldom found during childhood. Heart dicsease, characterized by endomyocardial fibrosis ...

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Loeffler’s Endocarditis due to Idiopathic Hypereosinophilic Syndrome

Introduction Hypereosinophilic syndrome (HES) is a rare disease characterized by persistent eosinophilia (>1,500 eosinophils× 10/L) for at least 6 months that remains unexplained in spite of a comprehensive evaluations and evidence of organ dysfunction primarily attributed to the eosinophilia. Loeffler’s endocarditis is a myocardial disease, thought to be secondary to idiopathic hypereosinophil...

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ژورنال

عنوان ژورنال: Arquivos Brasileiros de Cardiologia

سال: 2013

ISSN: 0066-782X

DOI: 10.5935/abc.20130081